In the presentation "Why Databases Don't Cloud Well and What To Do About It," David Stokes delves into the complexities of integrating databases with cloud computing and containerization tools, specifically Kubernetes. They highlight the inherent challenges due to the stateful and permanent nature of databases, contrasting with the ephemeral and stateless nature of containers. The talk suggests practical solutions such as using persistent storage, Database as a Service (DBaaS), and a reliable operator. The speaker also emphasizes the importance of best practices in database management, such as indexing, housekeeping, maintaining backups, and performance monitoring using tools like Percona Monitoring and Management (PMM).